2021 Barcelona Sporting Club season

The 2021 season was the 96th season in the existence of Barcelona Sporting Club, and the 63rd season in the top flight of Ecuadorian football. Barcelona was involved in three primary competitions: the main national tournament Liga Pro, the national cup called Copa Ecuador, and the international tournament Copa Libertadores.

The season was the second with Carlos Alfaro Moreno as president of the club. Barcelona's coach was Fabián Bustos. While the club failed to achieve domestic success, they did reach the semi-final stage of the Copa Libertadores for the fifth time in club history and the first time since 2017. They also contested the final of the Supercopa Ecuador.

Copa Ecuador
The 2021 Copa Ecuador was cancelled due to logistical issues surrounding the ongoing impacts of the COVID-19 pandemic in Ecuador.

Supercopa Ecuador
On 8 January 2021, FEF announced a February date and a four-team format for the Supercopa Ecuador to account for the cancellation of the 2020 Copa Ecuador. On 20 January 2021, Barcelona declined its participation in the competition to avoid a potential conflict with one of its sponsors.

After numerous delays, the FEF announced a late-June date for the tournament on 5 June 2021. FEF further modified the format of the tournament to include six-teams, with Barcelona returning to the draw. As reigning champions of Ecuador, Barcelona were given a bye to the semi-final stage.

Round of 16
Barcelona won 3–2 on aggregate and advanced to the quarter-finals.

Quarter-finals
''Tied 3–3 on aggregate. Barcelona advanced to the semi-finals via the away goals rule.''

Semi-finals
Flamengo won 4–0 on aggregate and advanced to the final.