2021 Berkeley Tennis Club Challenge – Singles

Madison Brengle was the defending champion but chose to compete at the 2021 Chicago Fall Tennis Classic instead.

Usue Maitane Arconada won the title, defeating Marcela Zacarías in the final, 6–1, 6–3.

Seeds
• # 🇨🇳 Zheng Saisai (first round)

• # 🇨🇳 Wang Xinyu (first round)

• # 🇭🇺 Panna Udvardy (first round)

• # 🇯🇵 Kurumi Nara (semifinals, retired)

• # 🇺🇸 Katie Volynets (first round)

• # 🇺🇸 Francesca Di Lorenzo (first round)

• # 🇯🇵 Mayo Hibi (semifinals)

• # Liang En-shuo (quarterfinals)