2021 Biella Challenger Indoor IV – Singles

Andreas Seppi was the defending champion but lost in the second round to Matthias Bachinger.

Daniel Masur won the title after defeating Bachinger 6–3, 6–7(8–10), 7–5 in the final.

Seeds
• # 🇫🇷 Lucas Pouille (second round)

• # 🇩🇪 Yannick Hanfmann (first round)

• # 🇮🇹 Andreas Seppi (second round)

• # 🇯🇵 Yūichi Sugita (first round)

• # 🇯🇵 Yasutaka Uchiyama (first round)

• # 🇧🇾 Ilya Ivashka (first round)

• # 🇫🇷 Grégoire Barrère (quarterfinals)

• # 🇫🇷 Benjamin Bonzi (semifinals)