2021 Biella Challenger V – Singles

Daniel Masur was the defending champion but chose not to defend his title.

Juan Pablo Varillas won the title after defeating Guido Andreozzi 6–3, 6–1 in the final.

Seeds
• # Pedro Sousa (first round)

• # 🇧🇴 Hugo Dellien (second round)

• # 🇺🇸 Mackenzie McDonald (second round)

• # 🇩🇪 Cedrik-Marcel Stebe (first round)

• # 🇮🇹 Federico Gaio (quarterfinals)

• # 🇫🇷 Hugo Gaston (first round)

• # 🇵🇪 Juan Pablo Varillas (champion)

• # 🇯🇵 Go Soeda (first round)