2021 Córdoba Open – Singles

Cristian Garín was the defending champion, but chose not to defend his title.

Juan Manuel Cerúndolo won the title, defeating Albert Ramos Viñolas in the final 6–0, 2–6, 6–2. Cerúndolo, who started the week ranked 335th and went through qualifying, became the first player to win a tournament on his ATP Tour debut since Santiago Ventura in 2004.

Seeds
The top four seeds received a bye into the second round. • #🇦🇷 Diego Schwartzman (quarterfinals)

• #🇫🇷 Benoît Paire (quarterfinals)

• #🇷🇸 Miomir Kecmanović (second round)

• #🇦🇷 Guido Pella (withdrew)

• #🇪🇸 Albert Ramos Viñolas (final)

• #🇩🇪 Dominik Koepfer (first round)

• #🇧🇷 Thiago Monteiro (quarterfinals)

• #🇦🇷 Federico Delbonis (second round)

Seeds
• # 🇦🇷 Facundo Bagnis (qualified)

• # 🇦🇷 Leonardo Mayer (first round)

• # 🇮🇳 Sumit Nagal (first round)

• # 🇵🇪 Juan Pablo Varillas (second round)

• # 🇪🇨 Emilio Gómez (first round)

• # 🇦🇷 Guido Andreozzi (first round)

• # João Domingues (first round)

• # 🇪🇸 Mario Vilella Martínez (first round)

Qualifiers
• # 🇦🇷 Facundo Bagnis

• # 🇦🇷 Tomás Martín Etcheverry

• # Marcelo Tomás Barrios Vera

• # 🇦🇷 Juan Manuel Cerúndolo

Lucky loser
• # 🇧🇷 João Menezes