2021 CAF Women's Champions League qualification

Qualification for the 2021 CAF Women's Champions League began on 24 July 2021 within UNAF for North Africa and WAFU Zone A for West Africa and concluded on 4 September 2021 within COSAFA for Southern Africa.

Qualification was situated within the 6 CAF sub-confederations. At the end of qualification, the qualified teams were reduced to the final 8 who would then proceed to the group stages of this edition of the tournament, which took place across two stadiums in Cairo, Egypt from 5 to 19 November 2021. These teams were composed of one winning team from each of the qualification competitions of the CAF sub-confederations (WAFU is split into two zones), the host nation's league-winning team and, for this edition only, an additional team from the sub-confederation of the 2018 Women's Africa Cup of Nations champions.

Teams
All participating teams qualified for their sub-regional qualification competitions via winning their respective national league titles and had their club licensing applications accepted by CAF. A total of 33 (out of 54) countries had at least one team which participated in this first qualification edition.

Associations which entered no team:



Qualification
Each CAF sub-confederation held a qualifying tournament, starting with UNAF for North Africa and WAFU Zone A for West Africa and ending with final for COSAFA's competition. The winners of these tournaments advanced to the group stages of the 2021 CAF Women's Champions League where they were joined by the host nation's league champions and another team from the sub-confederation of the 2018 Women's Africa Cup of Nations champions.

UNAF
The draw for this edition of qualification was held on 7 July 2021 with the competition itself running from 24 to 30 July in Berkane, Morocco and was won by the host nation's representative, AS FAR.

WAFU Zone A
The tournament took place in Mindelo, Cape Verde from 24 to 30 July with AS Mandé emerging as its representative after defeating AS Dakar Sacré-Cœur in the final.

WAFU Zone B
The tournament took place in Marcory, Ivory Coast from 24 July to 5 August 2021 with Hasaacas Ladies emerging as its representavie after beating Rivers Angels 3–1 in the final.

UNIFFAC
The qualification tournament for UNIFFAC teams was held from 1 to 29 August 2021. with Malabo Kings emerged as the UNNIFAC representative after beating FCF Amani 5–1 in the final.

CECAFA
The draw for the qualification tournament for CECAFA teams (branded as the CECAFA Women's Champions League) was held on 8 July 2021 with the competition itself running from 28 August to 9 September in Nairobi, Kenya. The host nation's team, Vihiga Queens emerged as the CECAFA representavie after beating Commercial Bank of Ehiopia (CBE) FC 2–1 in the final.

COSAFA
COSAFA organized a qualification tournament for its countries known as the COSAFA Women's Champions League to qualify its winners there, whose was held on 29 July 2021 with the competition itself taking place at the Sugar Ray Xulu Stadium in Durban, South Africa from 26 to 31 August 2021. Eight teams were drawn into two groups of four with the top two in each group advancing to the knock-out phase (semi-finals). Mamelodi Sundowns Ladies emerged as the COSAFA representative after beating Black Rhinos Queens 3–0 in the final.