2021 Cal Poly Mustangs football team

The 2021 Cal Poly Mustangs football team represented California Polytechnic State University in the 2021 NCAA Division I FCS football season. The Mustangs were led by 2nd-year head coach Beau Baldwin and played their home games at Alex G. Spanos Stadium, as members of the Big Sky Conference.

Polls
On July 26, 2021, during the virtual Big Sky Kickoff, the Mustangs were predicted to finish twelfth in the Big Sky by the coaches and last in the media.

Preseason All–Big Sky team
The Mustangs did not have any players selected to the preseason all-Big Sky team.