2021 Cary Challenger – Singles

Denis Kudla was the defending champion but chose not to defend his title.

Mitchell Krueger won the title after defeating Ramkumar Ramanathan 7–6(7–4), 6–2 in the final.

Seeds
• # 🇺🇸 Jenson Brooksby (withdrew)

• # 🇮🇳 Prajnesh Gunneswaran (quarterfinals)

• # 🇺🇸 Maxime Cressy (second round)

• # 🇺🇸 Bjorn Fratangelo (first round)

• # 🇸🇰 Lukáš Lacko (first round)

• # 🇺🇸 Mitchell Krueger (champion)

• # 🇺🇸 Christopher Eubanks (quarterfinals)

• # 🇮🇳 Ramkumar Ramanathan (final)