2021 Cary Challenger II – Singles

Mitchell Krueger was the defending champion and successfully defended his title.

Krueger won the title after defeating Bjorn Fratangelo 6–4, 6–3 in the final.

Seeds
• # 🇺🇸 Tennys Sandgren (first round, defaulted)

• # 🇺🇸 Denis Kudla (semifinals)

• # 🇮🇹 Salvatore Caruso (second round)

• # 🇦🇺 Alex Bolt (first round)

• # Jason Jung (first round)

• # 🇺🇸 Mitchell Krueger (champion)

• # 🇺🇸 Michael Mmoh (quarterfinals)

• # 🇺🇸 Bjorn Fratangelo (final)