2021 Challenger Città di Lugano – Singles

This was the first edition of the tournament.

Dominic Stricker won the title after defeating Vitaliy Sachko 6–4, 6–2 in the final, and as No. 874 became the lowest-ranked champion in Challenger history.

Seeds
• # 🇯🇵 Yūichi Sugita (semifinals)

• # 🇷🇺 Evgeny Donskoy (first round)

• # 🇩🇪 Peter Gojowczyk (first round)

• # 🇦🇺 Marc Polmans (first round)

• # 🇺🇦 Illya Marchenko (first round)

• # 🇷🇺 Roman Safiullin (quarterfinals)

• # 🇩🇪 Yannick Maden (withdrew)

• # 🇮🇹 Roberto Marcora (first round)