2021 Challenger La Manche – Singles

Roman Safiullin was the defending champion but chose not to defend his title.

Ruben Bemelmans won the title after defeating Lukáš Rosol 6–4, 6–4 in the final.

Seeds
• # 🇺🇸 Denis Kudla (second round)

• # 🇫🇷 Antoine Hoang (second round)

• # 🇫🇷 Arthur Rinderknech (semifinals)

• # 🇦🇹 Jurij Rodionov (second round)

• # 🇩🇪 Peter Gojowczyk (second round)

• # 🇪🇸 Bernabé Zapata Miralles (first round)

• # 🇺🇸 Brandon Nakashima (withdrew)

• # 🇦🇹 Sebastian Ofner (second round)