2021 Challenger de Santiago II – Doubles

Luis David Martínez and Gonçalo Oliveira were the defending champions but lost in the semifinals to Evan King and Max Schnur.

Diego Hidalgo and Nicolás Jarry won the title after defeating King and Schnur 6–3, 5–7, [10–6] in the final.

Seeds
• # 🇧🇷 Rafael Matos / 🇧🇷 Felipe Meligeni Alves (semifinals)

• # 🇻🇪 Luis David Martínez / Gonçalo Oliveira (semifinals)

• # 🇲🇽 Hans Hach Verdugo / 🇲🇽 Miguel Ángel Reyes-Varela (first round)

• # 🇺🇸 Evan King / 🇺🇸 Max Schnur (final)