2021 Chicago Fall Tennis Classic – Doubles

This was the first edition of the event.

Květa Peschke and Andrea Petkovic won the title, defeating Caroline Dolehide and CoCo Vandeweghe in the final, 6–3, 6–1. This was Petkovic's first WTA doubles title.

Elise Mertens was in contention to regain the WTA no. 1 doubles ranking by winning the title, but she and partner Hsieh Su-wei withdrew from the competition in the quarterfinals. Barbora Krejčíková accordingly retained the top ranking.

Seeds
The top four seeds received a bye into the second round. • # Hsieh Su-wei / 🇧🇪 Elise Mertens (Quarterfinal, withdrew)

• # 🇯🇵 Shuko Aoyama / 🇯🇵 Ena Shibahara (quarterfinals)

• # Alexa Guarachi / 🇺🇸 Desirae Krawczyk (quarterfinals)

• # 🇷🇺 Veronika Kudermetova / 🇺🇸 Bethanie Mattek-Sands (quarterfinals)

• # 🇺🇸 Nicole Melichar-Martinez / Demi Schuurs (semifinals)

• # Darija Jurak /  Andreja Klepač (semifinals)

• # 🇨🇦 Sharon Fichman / 🇲🇽 Giuliana Olmos (first round)

• # 🇨🇿 Marie Bouzková / 🇨🇿 Lucie Hradecká (second round)