2021 Chicago Women's Open – Doubles

This was the first edition of the tennis tournament.

Nadiia Kichenok and Raluca Olaru won the title, defeating Lyudmyla Kichenok and Makoto Ninomiya in the final, 7–6(8–6), 5–7, [10–8].

Seeds
• # 🇺🇸 Nicole Melichar / Demi Schuurs (quarterfinals)

• # Chan Hao-ching /  Latisha Chan (semifinals, withdrew)

• # 🇺🇦 Nadiia Kichenok / 🇷🇴 Raluca Olaru (champions)

• # 🇺🇦 Lyudmyla Kichenok / 🇯🇵 Makoto Ninomiya (final)