2021 Chicago Women's Open – Singles

This was the first edition of the tournament.

Elina Svitolina won the title, defeating Alizé Cornet in the final, 7–5, 6–4.

Seeds
• #🇺🇦 Elina Svitolina (champion)

• #🇮🇹 Camila Giorgi (withdrew)

• #🇷🇴 Sorana Cîrstea (first round)

• # Tamara Zidanšek (first round)

• #🇨🇿 Markéta Vondroušová (quarterfinals)

• # Viktorija Golubic (second round)

• #🇫🇷 Kristina Mladenovic (quarterfinals)

• #🇺🇦 Marta Kostyuk (quarterfinals)

• #🇫🇷 Alizé Cornet (final)

Seeds
• # 🇷🇺 Anastasia Potapova (first round)

• # 🇫🇷 Clara Burel (qualifying competition, lucky loser)

• # 🇷🇴 Ana Bogdan (qualified)

• # 🇰🇿 Zarina Diyas (qualified)

• # 🇮🇹 Sara Errani (withdrew)

• # 🇺🇸 Hailey Baptiste (first round)

• # 🇦🇺 Samantha Stosur (withdrew, still playing in Cincinnati)

• # 🇰🇷 Han Na-lae (qualifying competition)

Qualifiers
• # 🇺🇸 Quinn Gleason

• # Aldila Sutjiadi

• # 🇷🇴 Ana Bogdan

• # 🇰🇿 Zarina Diyas

Lucky loser
• # 🇫🇷 Clara Burel