2021 Chile Open – Singles

Cristian Garín defeated Facundo Bagnis in the final, 6–4, 6–7(3–7), 7–5 to capture the men's singles tennis title at the 2021 Chile Open.

Thiago Seyboth Wild was the defending champion, but chose not to defend his title.

Seeds
The top four seeds received a bye into the second round. • # Cristian Garín (champion)

• #🇫🇷 Benoît Paire (second round)

• #🇪🇸 Pablo Andújar (second round)

• #🇷🇸 Laslo Đere (quarterfinals)

• #🇺🇸 Frances Tiafoe (second round)

• #🇮🇹 Salvatore Caruso (first round)

• #🇦🇷 Federico Coria (second round)

• #🇦🇷 Federico Delbonis (semifinals)

Seeds
• # Alejandro Tabilo (qualified)

• # 🇵🇪 Juan Pablo Varillas (qualified)

• # 🇪🇨 Emilio Gómez (second round)

• # João Domingues (first round)

• # 🇪🇸 Mario Vilella Martínez (second round)

• # 🇧🇷 João Menezes (second round)

• # 🇦🇷 Andrea Collarini (first round)

• # 🇦🇷 Tomás Martín Etcheverry (second round)

Qualifiers
• # Alejandro Tabilo

• # 🇵🇪 Juan Pablo Varillas

• # Holger Rune

• # 🇦🇷 Sebastián Báez