2021 Christus Health Pro Challenge

The 2021 Christus Health Pro Challenge was a professional women's tennis tournament played on outdoor hard courts. It was the fifth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Tyler, Texas, United States between 25 and 31 October 2021.

Seeds

 * 1 Rankings are as of 18 October 2021.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇺🇸 Reese Brantmeier
 * 🇷🇺 Maria Kononova
 * 🇺🇸 Maria Mateas
 * 🇺🇸 Alana Smith

The following player received entry using a protected ranking:
 * 🇰🇷 Han Na-lae

The following players received entry from the qualifying draw:
 * 🇺🇸 Sophie Chang
 * 🇺🇸 Ellie Douglas
 * 🇷🇸 Katarina Kozarov
 * 🇺🇸 Ashlyn Krueger
 * 🇺🇸 Elizabeth Mandlik
 * 🇺🇸 Whitney Osuigwe
 * Aldila Sutjiadi
 * 🇺🇸 Amy Zhu

Singles

 * 🇯🇵 Misaki Doi def. 🇬🇧 Harriet Dart, 7–6(7–5), 6–2

Doubles

 * 🇲🇽 Giuliana Olmos / 🇲🇽 Marcela Zacarías def. 🇯🇵 Misaki Doi / 🇵🇱 Katarzyna Kawa, 7–5, 1–6, [10–5]