2021 Christus Health Pro Challenge – Singles

Ann Li was the defending champion but chose to compete at the 2021 Courmayeur Ladies Open instead.

Misaki Doi won the title, defeating Harriet Dart in the final, 7–6(7–5), 6–2.

Seeds
• # 🇺🇸 Madison Brengle (quarterfinals)

• # 🇺🇸 Claire Liu (quarterfinals)

• # 🇧🇷 Beatriz Haddad Maia (semifinals)

• # 🇯🇵 Misaki Doi (champion)

• # 🇬🇧 Harriet Dart (final)

• # 🇨🇳 Wang Xiyu (first round)

• # 🇺🇸 Caty McNally (quarterfinals)

• # 🇵🇱 Katarzyna Kawa (quarterfinals)