2021 Città di Como Challenger

The 2021 Città di Como Challenger was a professional tennis tournament played on clay courts. It was the fifteenth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Como, Italy between 30 August and 5 September 2021.

Seeds

 * 1 Rankings are as of 23 August 2021.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇮🇹 Flavio Cobolli
 * 🇮🇹 Francesco Forti
 * 🇮🇹 Federico Iannaccone

The following players received entry into the singles main draw using protected rankings:
 * 🇮🇹 Andrea Arnaboldi
 * 🇧🇪 Julien Cagnina
 * 🇩🇪 Julian Lenz

The following players received entry into the singles main draw as special exempts:
 * Nino Serdarušić
 * 🇦🇷 Camilo Ugo Carabelli

The following players received entry into the singles main draw as alternates:
 * 🇫🇷 Evan Furness
 * 🇮🇹 Giulio Zeppieri

The following players received entry from the qualifying draw:
 * 🇨🇾 Petros Chrysochos
 * 🇦🇹 Alexander Erler
 * 🇦🇹 Lucas Miedler
 * 🇮🇹 Andrea Vavassori

The following players received entry as lucky losers:
 * 🇮🇹 Franco Agamenone
 * 🇷🇺 Alexey Vatutin

Singles

 * 🇦🇷 Juan Manuel Cerúndolo def. 🇮🇹 Gian Marco Moroni 7–5, 7–6(9–7).

Doubles

 * 🇧🇷 Rafael Matos / 🇧🇷 Felipe Meligeni Alves def. 🇻🇪 Luis David Martínez / 🇮🇹 Andrea Vavassori 6–7(2–7), 6–4, [10–6].