2021 Città di Como Challenger – Singles

Facundo Mena was the defending champion but chose not to defend his title.

Juan Manuel Cerúndolo won the title after defeating Gian Marco Moroni 7–5, 7–6(9–7) in the final.

Seeds
• # 🇩🇪 Daniel Altmaier (semifinals, retired)

• # 🇸🇰 Jozef Kovalík (quarterfinals)

• # 🇸🇰 Andrej Martin (second round)

• # 🇦🇷 Juan Manuel Cerúndolo (champion)

• # 🇮🇹 Federico Gaio (second round)

• # 🇮🇳 Sumit Nagal (first round)

• # Marc-Andrea Hüsler (first round)

• # 🇮🇹 Alessandro Giannessi (withdrew)