2021 Cleveland Open

The 2021 Cleveland Open was a professional tennis tournament played on hard courts. It was the third edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Cleveland, Ohio, United States between March 15 and March 21, 2021.

Seeds

 * 1 Rankings are as of 8 March 2021.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇨🇦 Liam Draxl
 * 🇺🇸 Roy Smith
 * 🇺🇸 Zachary Svajda

The following players received entry into the singles main draw as alternates:
 * Lucas Catarina
 * 🇺🇸 Evan King
 * 🇨🇴 Nicolás Mejía

The following players received entry from the qualifying draw:
 * 🇺🇸 Felix Corwin
 * 🇨🇦 Alexis Galarneau
 * 🇺🇸 Aleksandar Kovacevic
 * 🇺🇸 Evan Song

Singles

 * 🇺🇸 Bjorn Fratangelo def. 🇺🇸 Jenson Brooksby 7–5, 6–4.

Doubles

 * 🇺🇸 Robert Galloway / 🇺🇸 Alex Lawson def. 🇺🇸 Evan King / 🇺🇸 Hunter Reese 7–5, 6–7(5–7), [11–9].