2021 Copa do Brasil third round

The 2021 Copa do Brasil third round was the third round of the 2021 Copa do Brasil football competition. It was played from 1 to 16 June 2021. A total of 32 teams competed in the third round to decide 16 places in the final rounds of the 2021 Copa do Brasil.

Draw
The draw for the third round was held on 23 April 2021, 14:00 at CBF headquarters in Rio de Janeiro. In a first draw, the 32 teams, seeded by their CBF ranking, were drawn into 16 ties. The home and away teams of each leg were decided in a second draw. CBF ranking is shown in parentheses.

Format
In the third round, each tie was played on a home-and-away two-legged basis. If the aggregate score was level, the second-leg match would go straight to the penalty shoot-out to determine the winners. 

Matches
All times are Brasília time, BRT (UTC−3) 


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Match 61
Santos won 3–0 on aggregate and advanced to the round of 16.

Match 62
Bahia won 2–0 on aggregate and advanced to the round of 16.

Match 63
Tied 1–1 on aggregate, CRB won on penalties and advanced to the round of 16.

Match 64
São Paulo won 11–4 on aggregate and advanced to the round of 16.

Match 65
Fluminense won 3–2 on aggregate and advanced to the round of 16.

Match 66
Fortaleza won 4–1 on aggregate and advanced to the round of 16.

Match 67
Grêmio won 2–0 on aggregate and advanced to the round of 16.

Match 68
Tied 2–2 on aggregate, Criciúma won on penalties and advanced to the round of 16.

Match 69
Athletico Paranaense won 2–1 on aggregate and advanced to the round of 16.

Match 70
Atlético Mineiro won 4–1 on aggregate and advanced to the round of 16.

Match 71
Atlético Goianiense won 2–0 on aggregate and advanced to the round of 16.

Match 72
Vitória won 3–2 on aggregate and advanced to the round of 16.

Match 73
Tied 1–1 on aggregate, Juazeirense won on penalties and advanced to the round of 16.

Match 74
ABC won 4–3 on aggregate and advanced to the round of 16.

Match 75
Flamengo won 3–0 on aggregate and advanced to the round of 16.

Match 76
Vasco da Gama won 2–1 on aggregate and advanced to the round of 16.