2021 Courmayeur Ladies Open

The 2021 Courmayeur Ladies Open was a women's tennis tournament played on indoor hard courts. It was the first edition of the Courmayeur Ladies Open, and part of the WTA 250 series of the 2021 WTA Tour. It was held at the Courmayeur Sport Center in Courmayeur, Italy, from 25 until 31 October, 2021.

Singles

 * Donna Vekić def. Clara Tauson 7–6(7–3), 6–2

This was Vekić's third WTA singles title, and first since 2017.

Doubles

 * 🇨🇳 Wang Xinyu / 🇨🇳 Zheng Saisai def. 🇯🇵 Eri Hozumi / 🇨🇳 Zhang Shuai 6–4, 3–6, [10–5]

Seeds

 * Rankings are as of October 18, 2021.

Other entrants
The following players received wildcards into the main draw:
 * 🇮🇹 Martina Caregaro
 * 🇮🇹 Jessica Pieri
 * 🇮🇹 Lucrezia Stefanini

The following players received entry using a protected ranking into the main draw:
 * 🇷🇺 Vitalia Diatchenko
 * 🇺🇦 Kateryna Kozlova
 * 🇱🇺 Mandy Minella

The following players received entry from the qualifying draw:
 * 🇪🇸 Aliona Bolsova
 * 🇪🇸 Cristina Bucșa
 * 🇮🇹 Martina Di Giuseppe
 * 🇮🇹 Giulia Gatto-Monticone
 * 🇩🇪 Stephanie Wagner
 * 🇨🇳 Zheng Qinwen

The following players received entry as lucky losers:
 * 🇵🇱 Urszula Radwańska
 * 🇮🇳 Ankita Raina

Withdrawals

 * Before the tournament
 * Belinda Bencic → replaced by 🇷🇺 Kamilla Rakhimova
 * 🇺🇸 Danielle Collins → replaced by 🇷🇺 Anna Kalinskaya
 * 🇮🇹 Camila Giorgi → replaced by 🇵🇱 Urszula Radwańska
 * 🇹🇳 Ons Jabeur → replaced by 🇮🇳 Ankita Raina
 * 🇨🇿 Tereza Martincová → replaced by 🇱🇺 Mandy Minella
 * 🇧🇪 Greet Minnen → replaced by Hsieh Su-wei
 * 🇪🇸 Nuria Párrizas Díaz → replaced by Donna Vekić
 * 🇰🇿 Elena Rybakina → replaced by 🇺🇦 Kateryna Kozlova
 * Maria Sakkari → replaced by Stefanie Vögele
 * 🇨🇿 Kateřina Siniaková → replaced by 🇮🇹 Lucia Bronzetti
 * 🇪🇸 Sara Sorribes Tormo → replaced by 🇵🇱 Magdalena Fręch

Seeds

 * Rankings are as of October 18, 2021.

Other entrants
The following pairs received wildcards into the doubles main draw:
 * 🇮🇹 Lucia Bronzetti / 🇮🇹 Martina Caregaro
 * 🇮🇹 Giulia Gatto-Monticone / 🇮🇹 Lisa Pigato

The following pair received entry as alternates:
 * 🇷🇺 Natalia Vikhlyantseva / 🇨🇳 Zheng Qinwen

Withdrawals

 * Before the tournament
 * 🇮🇹 Cristiana Ferrando / Hsieh Su-wei → replaced by 🇷🇺 Natalia Vikhlyantseva / 🇨🇳 Zheng Qinwen
 * Darija Jurak / Andreja Klepač → replaced by 🇷🇺 Vitalia Diatchenko / 🇷🇺 Alexandra Panova
 * 🇩🇪 Julia Lohoff / 🇷🇺 Kamilla Rakhimova → replaced by 🇪🇸 Aliona Bolsova / 🇷🇺 Kamilla Rakhimova