2021 Courmayeur Ladies Open – Singles

This was the first edition of the tournament.

Donna Vekić won her first title since 2017, defeating Clara Tauson in the final, 7–6(7–3), 6–2. Vekić didn't drop a set to win the tournament.

Seeds
• #🇹🇳 Ons Jabeur (withdrew)

• #🇮🇹 Camila Giorgi (withdrew)

• #🇷🇺 Liudmila Samsonova (semifinals)

• # Petra Martić (first round)

• # Clara Tauson (final)

• #🇺🇸 Alison Riske (second round)

• #🇮🇹 Jasmine Paolini (semifinals)

• #🇨🇳 Zhang Shuai (second round)

• #🇺🇸 Ann Li (quarterfinals)

• #🇺🇦 Dayana Yastremska (quarterfinals)

Seeds
• # 🇪🇸 Cristina Bucșa (qualified)

• # 🇨🇳 Zheng Qinwen (qualified)

• # 🇷🇺 Natalia Vikhlyantseva (first round)

• # 🇪🇸 Aliona Bolsova (qualified)

• # 🇮🇹 Giulia Gatto-Monticone (qualified)

• # 🇮🇳 Ankita Raina (qualifying competition, lucky loser)

• # 🇵🇱 Urszula Radwańska (qualifying competition, lucky loser)

• # 🇮🇹 Federica Di Sarra (qualifying competition)

• # 🇱🇺 Mandy Minella (moved to main draw)

• # 🇺🇸 Emina Bektas (first round)

• # 🇬🇧 Naiktha Bains (first round)

• # 🇮🇹 Martina Di Giuseppe (qualified)

Qualifiers
• # 🇪🇸 Cristina Bucșa

• # 🇨🇳 Zheng Qinwen

• # 🇩🇪 Stephanie Wagner

• # 🇪🇸 Aliona Bolsova

• # 🇮🇹 Giulia Gatto-Monticone

• # 🇮🇹 Martina Di Giuseppe

Lucky losers
• # 🇮🇳 Ankita Raina

• # 🇵🇱 Urszula Radwańska