2021 Dow Tennis Classic – Singles

Shelby Rogers was the defending champion, but chose not to participate.

Madison Brengle won the title, defeating Robin Anderson in the final, 6–2, 6–4.

Seeds
• # 🇺🇸 Madison Brengle (champion)

• # 🇯🇵 Misaki Doi (quarterfinals, retired)

• # 🇦🇺 Maddison Inglis (first round)

• # 🇬🇧 Harriet Dart (first round)

• # 🇺🇸 Caty McNally (semifinals)

• # 🇵🇱 Katarzyna Kawa (second round)

• # 🇦🇺 Lizette Cabrera (quarterfinals)

• # 🇺🇸 Hailey Baptiste (first round)

Seeds
• # 🇺🇸 Catherine Harrison (qualified)

• # 🇧🇪 Marie Benoît (qualifying competition)

• # 🇺🇸 Alexa Glatch (qualified)

• # 🇨🇦 Katherine Sebov (qualifying competition)

• # 🇹🇭 Peangtarn Plipuech (first round)

• # Aldila Sutjiadi (qualifying competition)

• # 🇺🇸 Sophie Chang (qualifying competition)

• # 🇯🇵 Nagi Hanatani (first round)

Qualifiers
• # 🇺🇸 Catherine Harrison

• # 🇺🇸 Dalayna Hewitt

• # 🇺🇸 Alexa Glatch

• # 🇺🇸 Ellie Douglas