2021 Dubai Tennis Championships – Women's singles

Garbiñe Muguruza defeated Barbora Krejčíková in the final, 7–6(8–6), 6–3 to win the women's singles tennis event at the 2021 Dubai Tennis Championships. Muguruza dropped just one set during the tournament, to Aryna Sabalenka in the quarterfinals.

Simona Halep was the reigning champion, but withdrew before the tournament due to an injury.

Seeds
The top eight seeds received a bye into the second round.

🇺🇦 Elina Svitolina (second round) 🇨🇿 Karolína Plíšková (third round) 🇧🇾 Aryna Sabalenka (quarterfinals) 🇨🇿 Petra Kvitová (second round, retired) Kiki Bertens (second round) Belinda Bencic (third round) 🇧🇾 Victoria Azarenka (withdrew) 🇵🇱 Iga Świątek (third round)

🇪🇸 Garbiñe Muguruza (champion) 🇧🇪 Elise Mertens (semifinals) 🇺🇸 Madison Keys (second round) 🇨🇿 Markéta Vondroušová (second round) Petra Martić (first round) 🇰🇿 Elena Rybakina (second round) 🇪🇪 Anett Kontaveit (third round) Maria Sakkari (first round)

Seeds
• # 🇪🇪 Kaia Kanepi (qualified)

• # 🇷🇴 Irina-Camelia Begu (qualified)

• # 🇯🇵 Misaki Doi (qualifying competition, lucky loser)

• # 🇮🇹 Martina Trevisan (qualifying competition, lucky loser)

• # 🇨🇳 Zhu Lin (first round)

• # 🇷🇴 Ana Bogdan (qualified)

• # 🇺🇦 Katarina Zavatska (qualified)

• # 🇧🇪 Ysaline Bonaventure (first round, retired)

• # 🇨🇿 Tereza Martincová (qualified)

• # 🇧🇬 Viktoriya Tomova (qualifying competition, lucky loser)

• # 🇷🇺 Vera Zvonareva (qualifying competition)

• # 🇺🇦 Lesia Tsurenko (qualified)

• # 🇷🇴 Monica Niculescu (first round)

• # 🇷🇺 Natalia Vikhlyantseva (first round)

• # 🇦🇹 Barbara Haas (qualifying competition, retired)

• # 🇷🇺 Kamilla Rakhimova (qualifying competition)

Qualifiers
• #🇪🇪 Kaia Kanepi

• #🇷🇴 Irina-Camelia Begu

• # Liang En-shuo

• #🇺🇦 Lesia Tsurenko

• #🇨🇿 Tereza Martincová

• #🇷🇴 Ana Bogdan

• #🇺🇦 Katarina Zavatska

• # Ana Konjuh

Lucky losers
• # 🇯🇵 Misaki Doi

• # 🇧🇬 Viktoriya Tomova

• # 🇮🇹 Martina Trevisan