2021 Emilia-Romagna Open – Women's singles

This was the first edition of the tournament.

Coco Gauff won the title, defeating Wang Qiang in the final, 6–1, 6–3.

Seeds
• #🇺🇸 Serena Williams (second round)

• # Petra Martić (quarterfinals)

• #🇺🇸 Coco Gauff (champion)

• #🇷🇺 Daria Kasatkina (second round)

• #🇺🇸 Amanda Anisimova (quarterfinals)

• #🇨🇳 Wang Qiang (final)

• #🇪🇸 Sara Sorribes Tormo (second round, retired)

• #🇫🇷 Caroline Garcia (quarterfinals)

Seeds
• # 🇷🇴 Ana Bogdan (moved to main draw)

• # 🇷🇺 Liudmila Samsonova (qualifying competition, lucky loser)

• # 🇺🇸 Caty McNally (qualified)

• # 🇩🇪 Anna-Lena Friedsam (qualified)

• # 🇨🇳 Wang Yafan (first round)

• # 🇸🇰 Anna Karolína Schmiedlová (qualified)

• # 🇺🇦 Katarina Zavatska (qualifying competition)

• # Stefanie Vögele (qualifying competition)

• # 🇵🇱 Katarzyna Kawa (first round)

• # Leonie Küng (first round)

• # 🇮🇹 Giulia Gatto-Monticone (Received main draw wildcard)

• # Lesley Pattinama Kerkhove (qualifying competition)

Qualifiers
• # 🇦🇷 Paula Ormaechea

• # 🇮🇹 Lisa Pigato

• # 🇺🇸 Caty McNally

• # 🇩🇪 Anna-Lena Friedsam

• # 🇮🇹 Martina Di Giuseppe

• # 🇸🇰 Anna Karolína Schmiedlová

Lucky loser
• # 🇷🇺 Liudmila Samsonova