2021 FINA World Swimming Championships (25 m) – Women's 100 metre individual medley

The Women's 100 metre individual medley competition of the 2021 FINA World Swimming Championships (25 m) will be held on 18 and 19 December 2021.

Records
Prior to the competition, the existing world and championship records were as follows.

Heats
The heats were started on 18 December at 10:12.

Semifinals
The semifinals were started on 18 December at 19:08.