2021 Florianópolis Challenger – Singles

This was the first edition of the tournament.

Igor Marcondes won the title after defeating Hugo Dellien 6–2, 6–4 in the final.

Seeds
• # Pablo Cuevas (quarterfinals, retired)

• # 🇧🇴 Hugo Dellien (final)

• # 🇧🇷 Thiago Seyboth Wild (first round)

• # 🇦🇷 Juan Ignacio Londero (semifinals)

• # 🇦🇷 Nicolás Kicker (second round)

• # 🇦🇷 Pedro Cachin (first round)

• # 🇦🇷 Andrea Collarini (first round)

• # 🇦🇷 Juan Pablo Ficovich (first round)