2021 French Open – Wheelchair men's singles

Defending champion Alfie Hewett defeated Shingo Kunieda in the final, 6–3, 6–4 to win the men's singles wheelchair tennis title at the 2021 French Open. It was his third French Open singles title and fifth major singles title overall.

Seeds
• # 🇯🇵 Shingo Kunieda (final)

• # 🇦🇷 Gustavo Fernández (semifinals)