2021 French Open – Wheelchair quad doubles

Two-time defending champion David Wagner and his partner Andy Lapthorne defeated the other defending champion Sam Schröder and his partner Dylan Alcott in the final, 7–6(7–1), 4–6, [10–7] to win the quad doubles wheelchair tennis title at the 2021 French Open. With the win, Lapthorne completed the career Grand Slam.

Schröder and Wagner were the defending champions, but did not participate together.