2021 French Open – Wheelchair women's singles

Diede de Groot defeated the defending champion Yui Kamiji in the final, 6–4, 6–3 to win the women's singles wheelchair tennis title at the 2021 French Open. It was the second step in an eventual Super Slam for de Groot, and she completed the double career Grand Slam with the win.

Seeds
• # Diede de Groot (champion)

• # 🇯🇵 Yui Kamiji (final)