2021 Garden Open

The 2021 Garden Open was a professional tennis tournament played on clay courts. It was the twelfth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Rome, Italy between 19 and 25 April 2021.

Seeds

 * 1 Rankings as of 12 April 2021.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇮🇹 Stefano Napolitano
 * 🇮🇹 Andrea Pellegrino
 * 🇮🇹 Giulio Zeppieri

The following player received entry into the singles main draw using a protected ranking:
 * 🇦🇺 Thanasi Kokkinakis

The following player received entry into the singles main draw as a special exempt:
 * 🇫🇷 Mathias Bourgue

The following players received entry into the singles main draw as alternates:
 * 🇦🇷 Andrea Collarini
 * Borna Gojo

The following players received entry from the qualifying draw:
 * 🇮🇹 Flavio Cobolli
 * 🇨🇿 Vít Kopřiva
 * 🇫🇷 Tristan Lamasine
 * 🇸🇰 Alex Molčan

Singles

 * 🇮🇹 Andrea Pellegrino def. 🇫🇷 Hugo Gaston 3–6, 6–2, 6–1.

Doubles

 * 🇫🇷 Sadio Doumbia / 🇫🇷 Fabien Reboul def. 🇮🇹 Paolo Lorenzi / 🇵🇪 Juan Pablo Varillas 7–6(7–5), 7–5.