2021 Georgia's Rome Tennis Open – Singles

This is the first edition of the tournament.

Irene Burillo Escorihuela won the title, defeating Grace Min in the final, 1–6, 7–6(7–4), 6–1.

Seeds
• # 🇧🇾 Olga Govortsova (second round)

• # 🇲🇽 Renata Zarazúa (first round)

• # 🇺🇸 Francesca Di Lorenzo (first round)

• # 🇸🇰 Kristína Kučová (second round)

• # 🇺🇸 Usue Maitane Arconada (quarterfinals)

• # 🇺🇸 Sachia Vickery (withdrew)

• # Verónica Cepede Royg (second round)

• # 🇨🇴 Camila Osorio (second round)