2021 Grand Est Open 88 – Singles

Katarina Zavatska was the defending champion but chose not to participate.

Anhelina Kalinina won the title, defeating Dalma Gálfi in the final, 6–2, 6–2.

Seeds
• # 🇮🇹 Martina Trevisan (first round)

• # 🇫🇷 Océane Dodin (quarterfinals)

• # Stefanie Vögele (first round)

• # 🇺🇦 Anhelina Kalinina (champion)

• # 🇭🇺 Réka Luca Jani (first round)

• # 🇨🇳 Zheng Qinwen (semifinals)

• # Jana Fett (second round, retired)

• # 🇭🇺 Dalma Gálfi (final)