2021 Hall of Fame Open – Singles

Kevin Anderson defeated Jenson Brooksby in the final, 7–6(10–8), 6–4, to win the singles tennis title at the 2021 Hall of Fame Open. It was played on outdoor grass courts and was part of the 250 series of the 2021 ATP Tour. It took place at the International Tennis Hall of Fame in Newport, Rhode Island, United States from 12 to 18 July 2021.

John Isner was the reigning champion from when the tournament was last held in 2019, but chose not to defend his title.

Seeds
The top four seeds receive a bye into the second round. • #🇰🇿 Alexander Bublik (semifinals)

• #🇺🇸 Sam Querrey (second round)

• #🇯🇵 Yoshihito Nishioka (second round)

• #🇨🇦 Vasek Pospisil (second round)

• #🇺🇸 Tennys Sandgren (second round)

• #🇺🇸 Steve Johnson (first round)

• #🇦🇺 Jordan Thompson (semifinals)

• # Kevin Anderson (champion)

Seeds
• # 🇦🇺 Alex Bolt (qualified)

• # 🇦🇹 Sebastian Ofner (qualified)

• # 🇸🇰 Lukáš Lacko (first round)

• # 🇺🇸 Mitchell Krueger (qualified)

• # 🇺🇸 Christopher Eubanks (first round)

• # 🇮🇳 Ramkumar Ramanathan (qualifying competition)

• # 🇧🇪 Ruben Bemelmans (qualifying competition)

• # 🇺🇸 Thai-Son Kwiatkowski (first round)

Qualifiers
• # 🇦🇺 Alex Bolt

• # 🇦🇹 Sebastian Ofner

• # 🇨🇦 Brayden Schnur

• # 🇺🇸 Mitchell Krueger