2021 Hampton Pirates football team

The 2021 Hampton Pirates football team represented the Hampton University as a member of the Big South Conference during the 2021 NCAA Division I FCS football season. Led by third-year head coach Robert Prunty, the Pirates played their home games at the Armstrong Stadium in Hampton, Virginia.

This was Hampton's final season as a member of the Big South Conference. The Pirates joined the Colonial Athletic Association (CAA) for all sports starting in 2022–23.

Big South poll
The Big South media days were held on July 27, 2021. In the conference preseason poll the Pirates were predicted to finish in seventh place.

Virginia Union
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At Old Dominion
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At Howard
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Norfolk State
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No. 17 Kennesaw State
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At Charleston Southern
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North Carolina A&T
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At Robert Morris
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Gardner–Webb
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At Campbell
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North Alabama
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