2021 Henderson Tennis Open

The 2021 Henderson Tennis Open was a professional women's tennis tournament played on outdoor hard courts. It was the twelfth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Henderson, Las Vegas, United States between 4 and 10 October 2021.

Seeds

 * 1 Rankings are as of 27 September 2021.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇺🇸 Haley Giavara
 * 🇺🇸 Rasheeda McAdoo
 * 🇺🇸 Shatoo Mohamad
 * 🇺🇸 Alexandra Riley

The following players received entry using protected rankings:
 * 🇺🇸 Louisa Chirico
 * 🇯🇵 Hiroko Kuwata

The following players received entry from the qualifying draw:
 * 🇮🇱 Shir Azran
 * 🇺🇸 Ibifuro Clement
 * 🇸🇪 Molly Helgesson
 * 🇺🇸 Tricia Mar
 * 🇺🇸 Rhiann Newborn
 * 🇺🇸 Erica Oosterhout
 * 🇺🇸 Holly Verner
 * 🇲🇽 Marcela Zacarías

Singles

 * 🇺🇸 Emina Bektas def. 🇯🇵 Yuriko Lily Miyazaki, 6–1, 6–1

Doubles

 * 🇺🇸 Quinn Gleason / 🇸🇰 Tereza Mihalíková def. 🇺🇸 Emina Bektas / 🇬🇧 Tara Moore, 7–6(7–5), 7–5