2021 Houston Baptist Huskies football team

The 2021 Houston Baptist Huskies football team represented Houston Baptist University—now known as Houston Christian University—as a member of the Southland Conference during the 2021 NCAA Division I FCS football season. Led by ninth-year head coach Vic Shealy the Huskies compiled an overall record of 0–11 with a mark of 0–8 in conference play, placing last out of six teams teams in the Southland. Houston Baptist played home games at Husky Stadium in Houston.

Preseason poll
The Southland Conference released their preseason poll in July 2021. The Huskies were picked to finish sixth in the conference. In addition, six Huskies were chosen to the Preseason All-Southland Team.

Preseason All–Southland Teams
Offense

1st Team
 * Christian Hood – Offensive Lineman, SO

2nd Team
 * Dreshawn Minnieweather – Running Back, SR

Defense

1st Team
 * Patrick Wolfe – Defensive Back, SR

2nd Team
 * Segun Ijiyera – Defensive Lineman, JR
 * Philip Ossai – Defensive Lineman, SO
 * Brennan Young – Linebacker, JR