2021 I.ČLTK Prague Open – Women's doubles

The women's doubles of the 2021 I.ČLTK Prague Open tournament was played on clay in Prague, Czech Republic.

Nicoleta Dascălu and Raluca Șerban were the defending champions, but chose not to participate.

Anna Bondár and Kimberley Zimmermann won the title, defeating Xenia Knoll and Elena-Gabriela Ruse in the final, 7–6(7–5), 6–2.

Seeds
• # Xenia Knoll / 🇷🇴 Elena-Gabriela Ruse (final)

• # 🇭🇺 Anna Bondár / 🇧🇪 Kimberley Zimmermann (champions)

• # 🇨🇿 Anastasia Dețiuc / 🇨🇿 Johana Marková (semifinals)

• # 🇩🇪 Tayisiya Morderger / 🇩🇪 Yana Morderger (quarterfinals)