2021 Iași Open – Singles

Carlos Taberner was the defending champion but chose not to defend his title.

Zdeněk Kolář won the title after defeating Hugo Gaston 7–5, 4–6, 6–4 in the final.

Seeds
• # 🇫🇷 Hugo Gaston (final)

• # 🇫🇷 Enzo Couacaud (first round)

• # 🇫🇷 Alexandre Müller (first round)

• # 🇧🇷 Felipe Meligeni Alves (semifinals)

• # 🇨🇿 Zdeněk Kolář (champion)

• # 🇷🇴 Marius Copil (second round)

• # 🇫🇷 Maxime Janvier (first round)

• # 🇧🇬 Dimitar Kuzmanov (quarterfinals)