2021 Internationaux de Strasbourg – Singles

Elina Svitolina was the defending champion but chose not to participate.

Barbora Krejčíková won her maiden WTA singles title, defeating Sorana Cîrstea in the final, 6–3, 6–3.

Seeds
• # 🇨🇦 Bianca Andreescu (quarterfinals, withdrew)

• # 🇺🇸 Jessica Pegula (first round)

• # 🇷🇺 Ekaterina Alexandrova (quarterfinals)

• # 🇰🇿 Yulia Putintseva (quarterfinals)

• # 🇨🇿 Barbora Krejčíková (champion)

• # 🇨🇳 Zhang Shuai (second round)

• # 🇺🇸 Shelby Rogers (second round)

• # 🇵🇱 Magda Linette (semifinals)

Seeds
• # 🇷🇺 Varvara Gracheva (moved to main draw)

• # 🇰🇿 Zarina Diyas (moved to main draw)

• # 🇺🇸 Christina McHale (moved to main draw)

• # 🇩🇪 Andrea Petkovic (qualifying competition)

• # 🇫🇷 Océane Dodin (qualified)

• # 🇫🇷 Chloé Paquet (first round)

• # 🇩🇪 Jule Niemeier (qualified)

• # Simona Waltert (qualifying competition)

• # 🇳🇴 Ulrikke Eikeri (first round)

• # 🇮🇹 Jessica Pieri (first round)

• # 🇨🇳 Zheng Qinwen (first round)

• # 🇧🇪 Maryna Zanevska (qualified)

Qualifiers
• # 🇧🇾 Yuliya Hatouka

• # 🇧🇪 Maryna Zanevska

• # 🇫🇷 Diane Parry

• # 🇩🇪 Jule Niemeier

• # 🇫🇷 Océane Dodin

• # 🇪🇸 Andrea Lázaro García