2021 Internationaux de Tennis de Vendée – Singles

Mikael Ymer was the defending champion but chose not to defend his title.

Jiří Veselý won the title after defeating Norbert Gombos 6–4, 6–4 in the final.

Seeds
• # 🇫🇷 Benjamin Bonzi (first round)

• # 🇨🇿 Jiří Veselý (champion)

• # 🇩🇪 Peter Gojowczyk (first round)

• # 🇮🇹 Andreas Seppi (semifinals)

• # 🇫🇷 Gilles Simon (first round, withdrew)

• # 🇫🇷 Pierre-Hugues Herbert (quarterfinals)

• # 🇱🇹 Ričardas Berankis (second round)

• # 🇸🇰 Norbert Gombos (final)