2021 Internazionali Femminili di Palermo

The 2021 Internazionali Femminili di Palermo was a professional women's tennis tournament played on outdoor clay courts at the Country Time Club. It was the 29th edition of the tournament and part of the 2021 WTA Tour. It took place in Palermo, Italy between 19 and 25 July 2021. First-seeded Danielle Collins won the singles title.

Singles

 * 🇺🇸 Danielle Collins defeated 🇷🇴 Elena-Gabriela Ruse, 6–4, 6–2.

Doubles

 * 🇳🇿 Erin Routliffe / 🇧🇪 Kimberley Zimmermann defeated 🇷🇺 Natela Dzalamidze / 🇷🇺 Kamilla Rakhimova 7–6(7–5), 4–6, [10–4]

Seeds

 * 1 Rankings are as of 12 July 2021.

Other entrants
The following players received wildcards into the main draw:
 * 🇮🇹 Nuria Brancaccio
 * 🇮🇹 Lucia Bronzetti
 * 🇮🇹 Lucrezia Stefanini
 * 🇨🇳 Zhang Shuai

The following player received entry using a protected ranking:
 * 🇷🇴 Alexandra Dulgheru
 * 🇱🇺 Mandy Minella

The following players received entry from the qualifying draw:
 * 🇪🇸 Marina Bassols Ribera
 * 🇩🇪 Katharina Gerlach
 * 🇷🇴 Elena-Gabriela Ruse
 * 🇨🇳 Zheng Qinwen

Withdrawals

 * Before the tournament
 * 🇷🇴 Sorana Cîrstea → replaced by Leonie Küng
 * 🇮🇹 Elisabetta Cocciaretto → replaced by 🇺🇸 Grace Min
 * 🇮🇹 Sara Errani → replaced by 🇪🇸 Lara Arruabarrena
 * Viktorija Golubic → replaced by 🇺🇸 Francesca Di Lorenzo
 * Ana Konjuh → replaced by 🇷🇴 Alexandra Dulgheru
 * 🇮🇹 Jasmine Paolini → replaced by 🇷🇴 Jaqueline Cristian
 * 🇺🇸 Bernarda Pera → replaced by 🇷🇸 Olga Danilović
 * 🇩🇪 Andrea Petkovic → replaced by 🇷🇺 Valeria Savinykh
 * Arantxa Rus → replaced by 🇷🇺 Natalia Vikhlyantseva
 * 🇷🇴 Patricia Maria Țig → replaced by 🇪🇸 Cristina Bucșa
 * 🇮🇹 Martina Trevisan → replaced by 🇮🇹 Giulia Gatto-Monticone
 * 🇲🇽 Renata Zarazúa → replaced by 🇷🇺 Vitalia Diatchenko
 * During the tournament
 * Jil Teichmann

Seeds

 * 1 Rankings are as of July 12, 2021.

Other entrants
The following pairs received wildcards into the doubles main draw:
 * 🇮🇹 Matilde Paoletti / 🇮🇹 Lisa Pigato
 * 🇮🇹 Camilla Rosatello / 🇮🇹 Dalila Spiteri

Withdrawals

 * Before the tournament
 * 🇦🇺 Lizette Cabrera / 🇦🇺 Maddison Inglis → replaced by 🇬🇧 Sarah Beth Grey / 🇬🇧 Emily Webley-Smith
 * 🇭🇺 Dalma Gálfi / 🇬🇧 Samantha Murray Sharan → replaced by 🇦🇺 Maddison Inglis / 🇬🇧 Samantha Murray Sharan
 * Beatrice Gumulya / Hsieh Yu-chieh → replaced by 🇪🇸 Lara Arruabarrena /  Beatrice Gumulya