2021 Internazionali Femminili di Palermo – Singles

Fiona Ferro was the defending champion, but she chose not to participate, as she was competing at the Summer Olympics.

Top seed Danielle Collins won her maiden WTA Tour singles title, defeating Elena-Gabriela Ruse in the final, 6–4, 6–2. Collins did not drop a set during the tournament.

Seeds
• # 🇺🇸 Danielle Collins (champion)

• # 🇷🇺 Liudmila Samsonova (first round)

• # Jil Teichmann (second round, withdrew)

• # 🇨🇳 Zhang Shuai (semifinals)

• # 🇧🇬 Viktoriya Tomova (first round)

• # 🇫🇷 Océane Dodin (semifinals)

• # 🇦🇺 Astra Sharma (quarterfinals)

• # 🇷🇺 Kamilla Rakhimova (first round)

Seeds
• # 🇷🇴 Elena-Gabriela Ruse (qualified)

• # 🇨🇳 Zheng Qinwen (qualified)

• # Despina Papamichail (qualifying competition)

• # 🇮🇹 Martina Di Giuseppe (qualifying competition)

• # 🇩🇪 Katharina Gerlach (qualified)

• # 🇬🇧 Samantha Murray Sharan (first round)

• # 🇪🇸 Marina Bassols Ribera (qualified)

• # 🇮🇹 Camilla Rosatello (qualifying competition)

Qualifiers
• # 🇷🇴 Elena-Gabriela Ruse

• # 🇨🇳 Zheng Qinwen

• # 🇩🇪 Katharina Gerlach

• # 🇪🇸 Marina Bassols Ribera