2021 Internazionali di Tennis Città di Perugia – Singles

Federico Delbonis was the defending champion but chose not to defend his title.

Tomás Martín Etcheverry won the title after defeating Vitaliy Sachko 7–5, 6–2 in the final.

Seeds
• # 🇮🇹 Salvatore Caruso (semifinals)

• # 🇸🇰 Andrej Martin (first round)

• # 🇮🇹 Federico Gaio (first round)

• # 🇨🇳 Zhang Zhizhen (second round)

• # 🇮🇹 Thomas Fabbiano (first round)

• # 🇰🇿 Dmitry Popko (first round)

• # 🇦🇷 Tomás Martín Etcheverry (champion)

• # 🇦🇷 Renzo Olivo (second round)