2021 Internazionali di Tennis Città di Todi – Singles

Yannick Hanfmann was the defending champion but chose not to defend his title.

Mario Vilella Martínez won the title after defeating Federico Gaio 7–6(7–3), 1–6, 6–3 in the final.

Seeds
• # 🇮🇹 Federico Gaio (final)

• # 🇪🇸 Mario Vilella Martínez (champion)

• # 🇰🇿 Dmitry Popko (second round)

• # 🇦🇷 Tomás Martín Etcheverry (semifinals)

• # 🇦🇷 Renzo Olivo (first round)

• # 🇦🇷 Andrea Collarini (second round)

• # 🇮🇹 Gian Marco Moroni (first round)

• # 🇮🇹 Lorenzo Giustino (first round)