2021 Internazionali di Tennis del Friuli Venezia Giulia – Singles

Bernabé Zapata Miralles was the defending champion but chose not to defend his title.

Francisco Cerúndolo won the title after defeating Tomás Martín Etcheverry 6–1, 6–2 in the final.

Seeds
• # 🇮🇹 Stefano Travaglia (quarterfinals)

• # 🇫🇷 Gilles Simon (first round)

• # 🇦🇷 Francisco Cerúndolo (champion)

• # 🇵🇪 Juan Pablo Varillas (quarterfinals)

• # 🇧🇴 Hugo Dellien (first round)

• # 🇫🇷 Antoine Hoang (first round)

• # 🇦🇷 Juan Manuel Cerúndolo (first round)

• # 🇮🇹 Federico Gaio (second round)