2021 Kentucky Bank Tennis Championships – Singles

Jannik Sinner was the defending champion but chose not to defend his title.

Jason Kubler won the title after defeating Alejandro Tabilo 7–5, 6–7(2–7), 7–5 in the final.

Seeds
• # 🇺🇸 Jenson Brooksby (quarterfinals)

• # 🇦🇺 Alex Bolt (withdrew)

• # 🇺🇸 Maxime Cressy (second round)

• # 🇮🇳 Prajnesh Gunneswaran (first round)

• # 🇪🇨 Emilio Gómez (first round)

• # Alejandro Tabilo (final)

• # 🇺🇸 Ernesto Escobedo (semifinals)

• # 🇦🇺 Thanasi Kokkinakis (semifinals)