2021 Koser Jewelers Tennis Challenge – Singles

Madison Brengle was the defending champion, having won the previous edition in 2019, but lost in the second round to Lesley Pattinama Kerkhove.

Nuria Párrizas Díaz won the title, defeating Greet Minnen in the final, 7–6(8–6), 4–6, 7–6(9–7).

Seeds
• # 🇺🇸 Madison Brengle (second round)

• # Clara Tauson (second round, retired)

• # 🇪🇸 Nuria Párrizas Díaz (champion)

• # 🇧🇪 Greet Minnen (final)

• # 🇺🇸 Varvara Lepchenko (withdrew)

• # 🇧🇪 Ysaline Bonaventure (first round)

• # 🇷🇺 Anna Kalinskaya (first round)

• # 🇺🇸 Caty McNally (quarterfinals)